University of Wisconsin–Madison

Research & Updates

Characterization of OCT biomarkers and endpoints in intermediate AMD

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Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and intergrader agreement for assessing intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers and endpoints in eyes with nonexudative AMD, relevant for clinical trials and AI development. Methods: Trained graders independently evaluated Heidelberg …

Diabetic Retinal Disease Characterization: Electronic Health Record Data Compared To Reading Center Grading Of Fundus Images

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Kristi Dohm, Mozhdeh Bahrainian, Nancy Barrett, Rick Voland, John Garrett, Jomol Mathew, Michael D. Abramoff, Barbara Blodi, Amitha Domalpally, Roomasa Channa Abstract Purpose: Validity of diabetic retinal disease (DRD) severity level as documented in electronic health record (EHR) data is crucial for research and patient care. Our goal was to assess the validity of DRD …

AI-based Measurement of GA Area for Screening In Clinical Trials

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Mohammed Younis, Robert D. Slater, Caleb Pacheco, Sairi Zhang, Rick Voland, Rachel E. Linderman, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop and validate a transfer learning model for measuring geographic atrophy (GA) area using ultrawide field (UWF) fundus autofluorescence (FAF) imaging. The model was initially trained and validated on Heidelberg Spectralis images and subsequently …

Methodology and Reproducibility of Nonperfusion Area on UWF-FA

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Mary Wilda, Rachel Halweg, Cynthia Hurtenbach, Kristi Dohm, Justin Parks, Ruth Shaw, Sheila Watson, Kari Moseman, Rick Voland, Barbara A. Blodi Abstract Purpose: To investigate the reproducibility of nonperfusion area measurements from ultrawide field fluorescein angiograms (UWF-FA) within each zone of the NetwORC grid and the reproducibility of change over time within each zone assessed …

Predicting Geographic Atrophy Risk Using Autofluorescence Imaging and Artificial Intelligence

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Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to delay or prevent GA development. Identifying precursors of GA can help target individuals at risk and develop effective interventions. The …

Comparison of GA measurements among ORC, OCT, and FAF imaging

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Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) derived from spectral domain-optical coherence tomography (SD-OCT) volume scans and to compare GA measurements among ORC, OCT, and fundus autofluorescence …

Correlating Fundus Flavoprotein Fluorescence with Structural Changes in Geographic Atrophy

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Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration (AMD). This study evaluates flavoprotein fluorescence (FPF), a novel biomarker of retinal distress, as a functional assessment tool for macular …

Prediction of Geographic Atrophy Enlargement using Various Deep Learning Approaches (2023)

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Amitha Domalpally, Robert Slater, Mark Banghart, Roomasa Channa, Donald S. Fong, Barbara Blodi Abstract Purpose: Fundus autofluorescence (FAF) imaging is used to monitor geographic atrophy (GA) growth inclinical trials. There is significant variability in the growth rate of GA with studies reporting between 0.5 – 2.6mm/year. Multiple imaging risk factors for rapid enlargement have been …

Longitudinal Analysis of Age-Related Macular Degeneration in the AMD Ryan Initiative Study (ARIS) (2023)

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Jeong W. Pak, Gelique Ayala, Cynthia Hurtenbach, Christine Orndahl, Tiarnan DL Keenan, Frederick L. Ferris, C. P Wilkinson, Traci Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year observational study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The AMD characteristics were followed longitudinally …

Comparison of Standard 7-Field, Clarus, and Optos Ultra-Widefield Imaging Systems for Diabetic Retinopathy Assessment (2023)

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Nancy Barrett, Nicole Duncan, Christian Kim, Sheila Watson, Andy Ewen, Lauren Kroth, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Advances in ultrawide-field color (UWF-C) imaging technology have enabled visualization of the entire retina. This study aims to determine whether diabetic retinopathy (DR) assessment with UWF-C imaging is comparable with the current gold standard, standard …