Rachel Linderman, Aadhi1 Balasubramanian, Madeline Pflasterer-Jennerjohn, Lucas Maakested, Jeong W. Pak, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To assess an artificial intelligence (AI)-based OCT segmentation with the ability to segment 7 different layer edges. This created 6 retinal thickness layers that are for age-related macular degeneration (AMD) clinical trials. Methods: …
Jeong W. Pak, David Lopez, Emily Y. Chew, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Reticular pseudodrusen (RPD) is associated with increased risk of progression to late age-related macular degeneration (AMD), particularly geographic atrophy (GA). While most studies focused on eyes with intermediate AMD, risk of RPD at earlier stages of disease has been less …
Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in eyes with nonexudative AMD. Methods: Trained graders independently evaluated Heidelberg OCT volume scans (20°x20°, 97 B scans) in eyes with …
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence (FAF), a primary outcome in clinical trials, does not correlate with visual function. Preservation of photoreceptors, particularly in the foveal …
Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and intergrader agreement for assessing intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers and endpoints in eyes with nonexudative AMD, relevant for clinical trials and AI development. Methods: Trained graders independently evaluated Heidelberg …
Jeong W. Pak, Gelique Ayala, Cynthia Hurtenbach, Christine Orndahl, Tiarnan DL Keenan, Frederick L. Ferris, C. P Wilkinson, Traci Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year observational study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The AMD characteristics were followed longitudinally …
Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled in the Age-Related Eye Disease Study 2 (AREDS2) from the University of Wisconsin were included. Subjects underwent SD-OCT, FAF and …
Andrew Dieu, Cynthia Hurtenbach, Jeong W. Pak, Tiarnan D. Keenan, Frederick L. Ferris, Charles P. Wilkinson, Christine Orndahl, Traci E. Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year, multicenter, international, prospective, observational cohort study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The …
Jeong W. Pak, Amitha Domalpally, Kyle McDaniel, Barbara Blodi Abstract Purpose: To evaluate growth rate and characteristics of bilateral geographic atrophy (GA) associated with age-related macular degeneration (AMD) from fundus color and autofluorescence images Methods: We evaluated fundus photographs (FP) and autofluorescence images (AF) in AMD patients with bilateral GA at baseline and 1 year …
Ronald P Danis, Amitha Domalpally, Ralph Trane, Jeong W Pak Abstract Purpose: To quantitatively evaluate the relationship between drusen area from photographs and drusen [a1.1]volume from SDOCT volume scans with respect to baseline association, AREDS Severity Scale, and change in these measurements over time. Methods: In a set of 88 eyes with non-advanced AMD (median …