University of Wisconsin–Madison

Research & Updates

Visual Correlation of OCT-Angiographic Features in Neovascular Age-Related Macular Degeneration (2023)

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Kevin Elwood, Rachel Linderman, Jeong Pak, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: OCT-Angiography (OCTA) presents numerous features with uncertain clinical significance in neovascular age-related macular degeneration (NVAMD). We performed a retrospective, observational, cross-sectional, clinical study to identify potential associations between OCTA features and visual acuity (VA) in eyes treated for NVAMD. Methods: Study …

Multimodal Assessment of Incomplete Retinal Pigment Epithelial Outer Retinal Atrophy (iRORA) and Nascent Geographic Atrophy (nGA) in Age-Related Macular Degeneration (2023)

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Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled in the Age-Related Eye Disease Study 2 (AREDS2) from the University of Wisconsin were included. Subjects underwent SD-OCT, FAF and …

A Comparison of Neovascular Age-Related Macular Degeneration Features in OCT Angiography and Fluorescein Angiography (2013)

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Jordan Winkler, Rachel Linderman, Jeong Pak, Mary Wilda, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Numerous pathological features in neovascular age-related macular degeneration (nAMD) can be assessed on both OCT-Angiography (OCTA) and fluorescein angiography (FA). We sought to compare macular neovascularization (MNV) and lesion area between OCTA and FA. Methods: OCTA and FA images …

Assessing Disorganization of Retinal Inner Layers in Long Term Follow Up of SCORE2 Trial (2023)

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Jonathan Le, Barbara Blodi, Amitha Domalpally, Rick Voland, Paul VanVeldhuisen, Neal Oden, Michael Ip, Ingrid U. Scott Abstract Purpose: To determine the association of disorganization of the retinal inner layers (DRIL) with central subfield thickness (CST) and visual acuity letter score (VALS) among participants of the Study of COmparative Treatments for REtinal Vein Occlusion 2 …

Imaging Features of Intraretinal Microvascular Abnormalities in Diabetic Retinopathy (2023)

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Christian Kim, Jeong W. Pak, Nancy Barrett, Nicole Duncan, Mary K. Wilda, Kristi Dohm, Jen Heathcote, Barbara. A. Blodi, Rick Voland, Amitha Domalpally Abstract Purpose: To compare characteristics of intraretinal microvascular abnormalities (IRMA) on color fundusphotography (CFP) to UWF-FA. We hypothesize that IRMA on CFP have similar characteristics tocorresponding lesions seen on UWF-FA. Methods: Participants …

Influence of Race on Training Data Quality for Artificial Intelligence (AI) Algorithms (2022)

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Amitha Domalpally, Rick Voland, Robert Slater, Ellie Corkery, Pamela Vargo, Rebecca Kuhtz, James Reimers, Roomasa Channa, Barbara Blodi Abstract Purpose: Diabetic retinopathy (DR) severity level is evaluated from stereoscopic 7-field color photographs by masked graders at the Wisconsin Reading Center and used as a reference standard for training and validation of AI algorithms. Training data …

Implementation of a Large-Scale Retinal Image Curation Workflow Using Deep Learning Framework (2022)

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Rohit Balaji, Jen Heathcote, Robert Slater, Nancy Barrett, Rick Voland, Vesna Tomic, Jared McDonald, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: The development of artificial intelligence (AI) algorithms for analyzing retinal pathologies requires training based on well-organized, labeled images. The goals of this project are to develop an AI model to curate 7-field retinal photographs …

Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials (2022)

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Nancy Barrett, Robert Slater, Roomasa Channa, Barbara Blodi, Amitha Domalpally Abstract Purpose: Preventive therapies to reduce progression of non-proliferative DR (NPDR) to proliferative DR are underway. Clinical trial enrollment criteria typically include a baseline DR severity scale (DRSS) of moderately severe (level 47) or severe NPDR (level 53) determined from stereoscopic 7-field retinal color photographs …

Multimodal Imaging Evaluation of Age-Related Macular Degeneration (AMD) in the AMD Ryan Initiative Study (ARIS) (2022)

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Andrew Dieu, Cynthia Hurtenbach, Jeong W. Pak, Tiarnan D. Keenan, Frederick L. Ferris, Charles P. Wilkinson, Christine Orndahl, Traci E. Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year, multicenter, international, prospective, observational cohort study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The …

Prevalence and Characteristics of Reticular Pseudodrusen in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2) (2021)

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Jeong W Pak, SC Cleland, Amitha Domalpally, Zhe Liu, Barbara Blodi, S Bailey, K Gehrs, R Wallace, L Tinker, and Julie A. Mares Abstract Purpose: Reticular pseudodrusen (RPD) have been identified as an independent risk factor in the progression of age-related macular degeneration (AMD), particularly predictive of geographic atrophy. However, RPD characteristics are poorly defined …