Thomas Saunders, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Area of geographic atrophy (GA) is a primary enrollment criterion in clinical trials. Current practices rely on clinicians to screen subjects for inclusion without a practical or reliable tool for GA area measurement, leading to screen failure rates as high as 50%. …
Cole Bacig, Nancy Barrett, Kristi Dohm, Amitha Domalpally, Barbara Blodi Abstract Purpose: The gold standard for diabetic retinopathy (DR) evaluation is the Early Treatment Diabetic Retinopathy Study (ETDRS) 12-step severity scale (DRSS), based on stereoscopic 7-Field (7F) color fundus photographs. Prior studies report moderate agreement between 7F and Ultra-Widefield (UWF) imaging for DR severity, with …
Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in eyes with nonexudative AMD. Methods: Trained graders independently evaluated Heidelberg OCT volume scans (20°x20°, 97 B scans) in eyes with …
Maria Schulz, Sairi Zhang, Jeong W. Pak, Rick Voland, Mark Banghart, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: This study compares two methods for assessing ellipsoid zone (EZ) loss on optical coherence tomography (OCT): traditional segmentation of EZ layers and edge detection of absent EZ. Automated assessments of EZ loss are used as endpoints in …
Bethany M. Erb, Elaine Botros, Thomas F. Saunders, Anna-Maria Haas, Rick Voland, Rachel Linderman, Barbara A. Blodi, Amitha Domalpally, Karl G. Csaky Abstract Purpose: Change in geographic atrophy (GA) area as measured by fundus autofluorescence (FAF), a primary outcome in clinical trials, does not correlate with visual function. Preservation of photoreceptors, particularly in the foveal …
Thomas Saunders, Jeong W. Pak, Rick Voland, Karl G. Csaky, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a multifactorial disease posing challenges in predicting progression. While prior studies have identified key risk factors on color photography and fundus autofluorescence (FAF), advancements in OCT have introduced novel biomarkers that warrant exploration. This …
Caleb Pacheco, Rachel E. Linderman, Madeline Pflasterer-Jennerjohn, Mark Banghart, Robert D. Slater, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop an artificial intelligence (AI) enabled OCT segmentation algorithm specifically tailored for diabetic macular edema (DME), capable of consistent performance across different OCT devices, addressing critical challenges in ophthalmic diagnostics. A secondary objective was to evaluate …
Jeong W. Pak, Thomas Saunders, Rick Voland, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is a complex disease with challenges in predicting its progression. While previous studies have highlighted key risk factors using fundus color and autofluorescence imaging, advancements in OCT have introduced novel biomarkers that require further investigation. This study aims …
Rushi N. Mankad, Madeline Pflasterer-Jennerjohn, Rachel E. Linderman, Robert Slater, Amitha Domalpally Abstract Purpose: The consensus of Atrophy (CAM) criteria provides a robust framework for evaluating geographic atrophy (GA) with optical coherence tomography (OCT) scans. However, the manual assessment of GA area based on these criteria is highly time-consuming and labor-intensive. This study aims to …
Nancy Barrett, Robert Slater, Rachel E. Linderman, Rick Voland, Claire Calhoun, Jennifer K. Sun, Barbara A. Blodi, Amitha Domalpally, with the DRCR Retina Network Abstract Purpose: Preventive strategies to slow progression of diabetic retinopathy (DR) are currently of interest.Clinical trials typically enroll patients at high risk of progression based on DR severity scores (DRSS), oftenmoderate …