University of Wisconsin–Madison

Tag: Posters

Multimodal Capture of the 15-year Incidence of Intermediate or Late Age-related Macular Degeneration (AMD) and its Association with Macular Pigment Optical Density (MPOD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS)

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Zhe Liu, Amitha Domalpally, Amy E. Millen, Barbara A. Blodi, Thomas P. Lawler, Billy R. Hammond, Steven T. Bailey, Robert B. Wallace, Karen M. Gehrs, Ronald Gangnon, Lesley Tinker, Julie A. Mares Abstract Purpose: Macular pigment, comprised of lutein (L) and zeaxanthin (Z), is hypothesized to reduce risk of AMD, but this association has not …

Accuracy of Longitudinal AI based EZ Loss Quantification on OCT in Geographic Atrophy

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Shelby Storm, Madeline Pflasterer-Jennerjohn, Robert Slater, Rachel Linderman, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Ellipsoid zone (EZ) loss is increasingly used as an endpoint in geographic atrophy (GA) trials, and AI algorithms are usually applied for automated EZ-loss area measurement. Most AI validations use cross-sectional datasets; however, therapeutic endpoints …

Real World Validation of Optos AI Algorithm for GA area Measurement

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Reeva Faisal, Caleb Pacheco, Robert Slater, Mohammed S. Younis, Jomol Matthew, Marine Nalbandyan, Amitha Domalpally, Roomasa Channa Abstract Purpose: Optos ultrawide field imaging is widely used in routine care to monitor Geographic Atrophy (GA) progression due to ease of imaging and comfort to patients. Our AI algorithm for GA quantification was originally developed and validated …

Multimodal Evaluation of Macular Atrophy Associated with Neovascular AMD

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Jordan Winkler, Jennifer Heathcote, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Macular atrophy (MA) contributes to visual decline in treated macular neovascularization (MNV), yet identifying MA on OCT in the presence of coexisting changes such as fluid, pigment epithelial detachments or fibrovascular tissue is challenging. We aimed to define the …

AI-based Multilayer OCT Segmentation Model For Macular Edema

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Justin Bitner, Rachel Linderman, Aadhi Balasubramanian, Madeline Pflasterer-Jennerjohn, Jeong W. Pak, Robert Slater, Roomasa Channa, Lucas Maakested, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To train and assess an artificial intelligence (AI)-based OCT segmentation with the ability to segment 6 different layer edges. This created 5 different retinal thickness layers that are commonly requested for …

Association of RPD with Early Stage of AMD

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Jeong W. Pak, David Lopez, Emily Y. Chew, Barbara A. Blodi,  Amitha Domalpally Abstract Purpose: Reticular pseudodrusen (RPD) is associated with increased risk of progression to late age-related macular degeneration (AMD), particularly geographic atrophy (GA). While most studies focused on eyes with intermediate AMD, risk of RPD at earlier stages of disease has been less …

Real World Deployment of a Prescreening Algorithm for Geographic Atrophy

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Thomas Saunders, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Area of geographic atrophy (GA) is a primary enrollment criterion in clinical trials. Current practices rely on clinicians to screen subjects for inclusion without a practical or reliable tool for GA area measurement, leading to screen failure rates as high as 50%. …

Comparison of Lesion Annotation Across 7-Field and Ultrawide Field Imaging in Diabetic Retinopathy (COLA)

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Cole Bacig, Nancy Barrett, Kristi Dohm, Amitha Domalpally, Barbara Blodi Abstract Purpose: The gold standard for diabetic retinopathy (DR) evaluation is the Early Treatment Diabetic Retinopathy Study (ETDRS) 12-step severity scale (DRSS), based on stereoscopic 7-Field (7F) color fundus photographs. Prior studies report moderate agreement between 7F and Ultra-Widefield (UWF) imaging for DR severity, with …

Characterizing Intermediate AMD Biomarkers on OCT: Methods and Reproducibility

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Jennifer Heathcote, Jordan Winkler, Jeong W. Pak, Rick Voland, Barbara Blodi, Amitha Domalpally Abstract Purpose: To define evaluation criteria and assess intergrader agreement for intermediate Age-related Macular Degeneration (iAMD) optical coherence tomography (OCT) biomarkers in eyes with nonexudative AMD. Methods: Trained graders independently evaluated Heidelberg OCT volume scans (20°x20°, 97 B scans) in eyes with …

Comparison of Measurement Techniques for Photoreceptor Loss in Geographic Atrophy

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Maria Schulz, Sairi Zhang, Jeong W. Pak, Rick Voland, Mark Banghart, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: This study compares two methods for assessing ellipsoid zone (EZ) loss on optical coherence tomography (OCT): traditional segmentation of EZ layers and edge detection of absent EZ. Automated assessments of EZ loss are used as endpoints in …