University of Wisconsin–Madison

Tag: Diabetic Retinopathy

UWF-Based Diabetic Retinopathy (DR) Prescreening Using a Novel Patch-Based AI Model

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Nancy Barrett, Varsha Satish, Robert Slater, Thomas Saunders, Rachel Linderman, Barbara Blodi, Amitha Domalpally Abstract Purpose: Ultra-widefield (UWF) color photographs are widely used in clinical practice and clinical trials because they capture the entire retina with minimal patient burden. Trial eligibility includes DR severity, distinguishing moderately severe NPDR (ETDRS ≥47) from lower severity levels. However, …

Comparison of Lesion Annotation Across 7-Field and Ultrawide Field Imaging in Diabetic Retinopathy (COLA)

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Cole Bacig, Nancy Barrett, Kristi Dohm, Amitha Domalpally, Barbara Blodi Abstract Purpose: The gold standard for diabetic retinopathy (DR) evaluation is the Early Treatment Diabetic Retinopathy Study (ETDRS) 12-step severity scale (DRSS), based on stereoscopic 7-Field (7F) color fundus photographs. Prior studies report moderate agreement between 7F and Ultra-Widefield (UWF) imaging for DR severity, with …

Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials

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Nancy Barrett, Robert Slater, Rachel E. Linderman, Rick Voland, Claire Calhoun, Jennifer K. Sun, Barbara A. Blodi, Amitha Domalpally, with the DRCR Retina Network Abstract Purpose: Preventive strategies to slow progression of diabetic retinopathy (DR) are currently of interest.Clinical trials typically enroll patients at high risk of progression based on DR severity scores (DRSS), oftenmoderate …

Methodology and Reproducibility of Nonperfusion Area on UWF-FA

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Mary Wilda, Rachel Halweg, Cynthia Hurtenbach, Kristi Dohm, Justin Parks, Ruth Shaw, Sheila Watson, Kari Moseman, Rick Voland, Barbara A. Blodi Abstract Purpose: To investigate the reproducibility of nonperfusion area measurements from ultrawide field fluorescein angiograms (UWF-FA) within each zone of the NetwORC grid and the reproducibility of change over time within each zone assessed …

Comparison of Standard 7-Field, Clarus, and Optos Ultra-Widefield Imaging Systems for Diabetic Retinopathy Assessment (2023)

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Nancy Barrett, Nicole Duncan, Christian Kim, Sheila Watson, Andy Ewen, Lauren Kroth, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Advances in ultrawide-field color (UWF-C) imaging technology have enabled visualization of the entire retina. This study aims to determine whether diabetic retinopathy (DR) assessment with UWF-C imaging is comparable with the current gold standard, standard …

Artificial Intelligence (AI) enabled pre-screening for Diabetic Retinopathy (DR) clinical trials (2022)

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Nancy Barrett, Robert Slater, Roomasa Channa, Barbara Blodi, Amitha Domalpally Abstract Purpose: Preventive therapies to reduce progression of non-proliferative DR (NPDR) to proliferative DR are underway. Clinical trial enrollment criteria typically include a baseline DR severity scale (DRSS) of moderately severe (level 47) or severe NPDR (level 53) determined from stereoscopic 7-field retinal color photographs …

Comparison of Diabetic Retinopathy Severity Level Assessment Between Standard 7-field Imaging and Ultrawide Field Color Imaging (2019)

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Kristi Dohm, Nancy Barrett, Kyle McDaniel, Barbara Blodi, Amitha Domalpally Abstract Purpose: Diabetic retinopathy has traditionally been evaluated using the Early Treatment Diabetic Retinopathy Severity Scale (ETDRS) from 7-field (7F) stereoscopic color photographs and is considered the gold standard. Ultrawide field color (UWF-C) imaging has recently become available for viewing a wider area of the …

Correlation of peripheral non-perfusion from ultrawide field fluorescein angiography to color ETDRS severity level in eyes with diabetic retinopathy (2019)

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Ellie Corkery, Kyle McDaniel, Amitha Domalpally, Barbara Blodi Abstract Purpose: To assess the correlation between peripheral non-perfusion from ultrawide field fluorescein angiography (UWF FA) and Early Treatment Diabetic Retinopathy Severity (ETDRS) level from color fundus photographs (FP) of eyes with diabetic retinopathy (DR). Methods: Capillary non-perfusion was evaluated from UWF FA (Optos) images in three …

Correlation of Optical Coherence Tomography Angiography Vascular Density to Color ETDRS Severity Level in Eyes with Diabetic Retinopathy (2018)

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Ellie Corkery, Amitha Domalpally, Dawn Myers, Jeong W. Pak, Ralph Trane, Barbara Blodi Abstract Purpose: Diabetic retinopathy severity is evaluated using color fundus photographs (FP) employing the Early Treatment Diabetic Retinopathy Severity (ETDRS) scale. Optical Coherence Tomography Angiography (OCTA) is a recently developed imaging technique that generates volumetric angiography including an enface view of the …

Comparison of Foveal Avascular Zone Metrics in Diabetic Retinopathy (2018)

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Kimberly Stepien, Ellie Corkery, Sheila Watson, Cynthia Hurtenbach, Ralph Trane, Jeong Won Pak, Amitha Domalpally Abstract Purpose: Foveal avascular zone (FAZ) abnormalities are known in diabetic retinopathy (DR) and may prove useful as a biomarker in DR diagnosis and management. Fundus photography and fluorescein angiography (FA) as shown in the ETDRS are the gold standard …