Mary K. Wilda, Ellie Corkery, Cynthia Hurtenbach, Amitha Domalpally, Ralph Trane, Barbara A. Blodi Abstract Purpose: Considered the gold standard in assessing location of choroidal neovascular (CNV) lesions, fluorescin angiography (FA) is the primary imaging modality used to determine CNV lesion eligibility in clinical trials. With structural spectral domain optical coherence tomography (SD-OCT), it is …
Amitha Domalpally, Ralph Trane, James Reimers, Barbara Blodi Abstract Purpose: The Early Treatment Diabetic Retinopathy Study (ETDRS) study established a 12 step scale to document the severity of diabetic retinopathy (DR) using 7 field stereoscopic color fundus photographs (CFP). The ETDRS scale is used as an outcome in clinical trials. We compared reproducibility in the …
Ellie Corkery, Amitha Domalpally, Ruth Shaw, Kelly Warren, Sheila Watson, Barbara Blodi Abstract Purpose: According to the October 2016 Report from the NEI/FDA Diabetic Retinopathy Clinical Trial Design and Endpoints workshop (Investigative Ophthalmology & Visual Science October 2016, Vol.57, 5127-5142.), “Change in retinal capillary nonperfusion area over time as measured with UWF fluorescein angiography to …
Gregory Sovinski, Amitha Domalpally, Dawn Myers, Yijun Huang, Barbara Blodi Abstract Purpose: Central Retinal Thickness (CRT) is a measure derived from Optical Coherence Tomography (OCT) scans and is an important outcome in clinical trials. Differences in segmentation algorithms among various commercial OCT machines leads to variability in CRT in the same eye and results in …
Ronald P Danis, Amitha Domalpally, Ralph Trane, Jeong W Pak Abstract Purpose: To quantitatively evaluate the relationship between drusen area from photographs and drusen [a1.1]volume from SDOCT volume scans with respect to baseline association, AREDS Severity Scale, and change in these measurements over time. Methods: In a set of 88 eyes with non-advanced AMD (median …
Eric Weinlander, Amitha Domalpally, Ellie Corkery, Barbara Blodi Abstract Purpose: Spectral domain optical coherence tomography (SD-OCT) has not routinely been used to measure features of polypoidal choroidal vasculopathy (PCV) due to its anatomic complexity. We hypothesize that a novel algorithm-based semi-automated approach to grading SD-OCT will overcome this difficulty to yield reliable and accurate measurements …
Amitha Domalpally, Yijun Huang, Dawn Myers, Taylor Starnes, Zhe Liu, Ronald P. Danis, Barbara A. Blodi Abstract Purpose: To compare retinal pigment epithelium (RPE) and retinal thickness assessments made with SDOCTin eyes with dry AMD and normal eyes. Methods: Eyes with intermediate AMD or worse in participants between 50 – 85 years of age were …
Amitha Domalpally, Ronald Danis, Emily Chew, Srinivas Sadda, Traci Clemons, Thomas R Friberg, and the AREDS2 Research Group Abstract Purpose: To characterize abnormalities in the peripheral retina using ultrawidefield (UWF) autofluorescence (AF) images in eyes with age related macular degeneration (AMD) Methods: UWF images (200 degrees) centered on the posterior pole as well as steered …
Erika Treichel, Amitha Domalpally, Ronald Danis, Susan Reed, Ashwini Narkar, Traci Clemons, Emily Chew, and the AREDS2 Research Group Abstracts Purpose: To describe the methodology for evaluation of cortical and posterior subcapsular cataracts using digital fundus reflex photographs and the baseline lens data in AREDS2. The goal of AREDS2 is to study the effects of …
Yijun Huang, Ronald P Danis, Jeong W. Pak, Shiyu Luo, James White, Xian Zhang, Ashwini Narkar, Amitha Domalpally Abstract Purpose: To develop a computer-aided manual segmentation method (EdgeSelect) for SD-OCT images, and compare its segmented results with those using a traditional manual segmentation (Manual) method. Methods: 3D Spectralis SD-OCT images (Heidelberg Inc., Germany) covering the …