Tag: ARVO 2026

Multimodal Capture of the 15-year Incidence of Intermediate or Late Age-related Macular Degeneration (AMD) and its Association with Macular Pigment Optical Density (MPOD) in the Carotenoids in Age-Related Eye Disease Study (CAREDS)

Posted on April 23, 2026

Zhe Liu, Amitha Domalpally, Amy E. Millen, Barbara A. Blodi, Thomas P. Lawler, Billy R. Hammond, Steven T. Bailey, Robert B. Wallace, Karen M. Gehrs, Ronald Gangnon, Lesley Tinker, Julie A. Mares Abstract Purpose: Macular pigment, comprised of lutein (L) and zeaxanthin (Z), is hypothesized to reduce risk of AMD, but this association has not …

Accuracy of Longitudinal AI based EZ Loss Quantification on OCT in Geographic Atrophy

Posted on April 13, 2026

Shelby Storm, Madeline Pflasterer-Jennerjohn, Robert Slater, Rachel Linderman, Jeong W. Pak, David Lopez, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Ellipsoid zone (EZ) loss is increasingly used as an endpoint in geographic atrophy (GA) trials, and AI algorithms are usually applied for automated EZ-loss area measurement. Most AI validations use cross-sectional datasets; however, therapeutic endpoints …

Real World Validation of Optos AI Algorithm for GA area Measurement

Posted on April 13, 2026

Reeva Faisal, Caleb Pacheco, Robert Slater, Mohammed S. Younis, Jomol Matthew, Marine Nalbandyan, Amitha Domalpally, Roomasa Channa Abstract Purpose: Optos ultrawide field imaging is widely used in routine care to monitor Geographic Atrophy (GA) progression due to ease of imaging and comfort to patients. Our AI algorithm for GA quantification was originally developed and validated …

UWF-Based Diabetic Retinopathy (DR) Prescreening Using a Novel Patch-Based AI Model

Posted on April 13, 2026

Nancy Barrett, Varsha Satish, Robert Slater, Thomas Saunders, Rachel Linderman, Barbara Blodi, Amitha Domalpally Abstract Purpose: Ultra-widefield (UWF) color photographs are widely used in clinical practice and clinical trials because they capture the entire retina with minimal patient burden. Trial eligibility includes DR severity, distinguishing moderately severe NPDR (ETDRS ≥47) from lower severity levels. However, …

AI-based Multilayer OCT Segmentation Model For Macular Edema

Posted on April 13, 2026

Justin Bitner, Rachel Linderman, Aadhi Balasubramanian, Madeline Pflasterer-Jennerjohn, Jeong W. Pak, Robert Slater, Roomasa Channa, Lucas Maakested, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: To train and assess an artificial intelligence (AI)-based OCT segmentation with the ability to segment 6 different layer edges. This created 5 different retinal thickness layers that are commonly requested for …

Real World Deployment of a Prescreening Algorithm for Geographic Atrophy

Posted on April 13, 2026

Thomas Saunders, Robert Slater, Roomasa Channa, Barbara A. Blodi, Amitha Domalpally Abstract Purpose: Area of geographic atrophy (GA) is a primary enrollment criterion in clinical trials. Current practices rely on clinicians to screen subjects for inclusion without a practical or reliable tool for GA area measurement, leading to screen failure rates as high as 50%. …