University of Wisconsin–Madison

Tag: Posters

Predicting Geographic Atrophy Risk Using Autofluorescence Imaging and Artificial Intelligence

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Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to delay or prevent GA development. Identifying precursors of GA can help target individuals at risk and develop effective interventions. The …

Comparison of GA measurements among ORC, OCT, and FAF imaging

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Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) derived from spectral domain-optical coherence tomography (SD-OCT) volume scans and to compare GA measurements among ORC, OCT, and fundus autofluorescence …

Correlating Fundus Flavoprotein Fluorescence with Structural Changes in Geographic Atrophy

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Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration (AMD). This study evaluates flavoprotein fluorescence (FPF), a novel biomarker of retinal distress, as a functional assessment tool for macular …

Prediction of Geographic Atrophy Enlargement using Various Deep Learning Approaches (2023)

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Amitha Domalpally, Robert Slater, Mark Banghart, Roomasa Channa, Donald S. Fong, Barbara Blodi Abstract Purpose: Fundus autofluorescence (FAF) imaging is used to monitor geographic atrophy (GA) growth inclinical trials. There is significant variability in the growth rate of GA with studies reporting between 0.5 – 2.6mm/year. Multiple imaging risk factors for rapid enlargement have been …

Longitudinal Analysis of Age-Related Macular Degeneration in the AMD Ryan Initiative Study (ARIS) (2023)

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Jeong W. Pak, Gelique Ayala, Cynthia Hurtenbach, Christine Orndahl, Tiarnan DL Keenan, Frederick L. Ferris, C. P Wilkinson, Traci Clemons, Emily Y. Chew, Amitha Domalpally Abstract Purpose: ARIS is a 5-year observational study of participants with early AMD or reticular pseudodrusen (RPD) to identify novel biomarkers of disease progression. The AMD characteristics were followed longitudinally …

Comparison of Standard 7-Field, Clarus, and Optos Ultra-Widefield Imaging Systems for Diabetic Retinopathy Assessment (2023)

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Nancy Barrett, Nicole Duncan, Christian Kim, Sheila Watson, Andy Ewen, Lauren Kroth, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Advances in ultrawide-field color (UWF-C) imaging technology have enabled visualization of the entire retina. This study aims to determine whether diabetic retinopathy (DR) assessment with UWF-C imaging is comparable with the current gold standard, standard …

Visual Correlation of OCT-Angiographic Features in Neovascular Age-Related Macular Degeneration (2023)

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Kevin Elwood, Rachel Linderman, Jeong Pak, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: OCT-Angiography (OCTA) presents numerous features with uncertain clinical significance in neovascular age-related macular degeneration (NVAMD). We performed a retrospective, observational, cross-sectional, clinical study to identify potential associations between OCTA features and visual acuity (VA) in eyes treated for NVAMD. Methods: Study …

Multimodal Assessment of Incomplete Retinal Pigment Epithelial Outer Retinal Atrophy (iRORA) and Nascent Geographic Atrophy (nGA) in Age-Related Macular Degeneration (2023)

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Gelique Ayala, Jeong Pak, Kenny Taylor, Cynthia Hurtenbach, Barbara Blodi, and Amitha Domalpally Abstract Purpose: To compare SD-OCT defined iRORA and nGA lesions to Fundus Autofluorescence (FAF) and Color Fundus Photography (CFP) Methods: Subjects enrolled in the Age-Related Eye Disease Study 2 (AREDS2) from the University of Wisconsin were included. Subjects underwent SD-OCT, FAF and …

A Comparison of Neovascular Age-Related Macular Degeneration Features in OCT Angiography and Fluorescein Angiography (2013)

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Jordan Winkler, Rachel Linderman, Jeong Pak, Mary Wilda, Rick Voland, Amitha Domalpally, Barbara Blodi Abstract Purpose: Numerous pathological features in neovascular age-related macular degeneration (nAMD) can be assessed on both OCT-Angiography (OCTA) and fluorescein angiography (FA). We sought to compare macular neovascularization (MNV) and lesion area between OCTA and FA. Methods: OCTA and FA images …

Assessing Disorganization of Retinal Inner Layers in Long Term Follow Up of SCORE2 Trial (2023)

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Jonathan Le, Barbara Blodi, Amitha Domalpally, Rick Voland, Paul VanVeldhuisen, Neal Oden, Michael Ip, Ingrid U. Scott Abstract Purpose: To determine the association of disorganization of the retinal inner layers (DRIL) with central subfield thickness (CST) and visual acuity letter score (VALS) among participants of the Study of COmparative Treatments for REtinal Vein Occlusion 2 …