Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) derived from spectral domain-optical coherence tomography (SD-OCT) volume scans and to compare GA measurements among ORC, OCT, and fundus autofluorescence …
Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration (AMD). This study evaluates flavoprotein fluorescence (FPF), a novel biomarker of retinal distress, as a functional assessment tool for macular …
Amitha Domalpally, Robert Slater, Mark Banghart, Roomasa Channa, Donald S. Fong, Barbara Blodi Abstract Purpose: Fundus autofluorescence (FAF) imaging is used to monitor geographic atrophy (GA) growth inclinical trials. There is significant variability in the growth rate of GA with studies reporting between 0.5 – 2.6mm/year. Multiple imaging risk factors for rapid enlargement have been …
Jeong W. Pak, Amitha Domalpally, Elivira Agron, Ronald Danis, Traci E. Clemons, Emily Y. Chew, and the AREDS2 Research Group Abstract Purpose: To identify risk factors for progression of geographic atrophy (GA) from autofluoresence (AF) images in eyes with age-related macular degeneration (AMD) Methods: AF images from the Age-Related Eye Disease Study 2 (AREDS2) ancillary …
Ronald P. Danis, Amitha Domalpally, Ellie Corkery, Ruth Shaw, Ashwini Narkar, Jim White Abstract Purpose: Given that baseline area and configuration of GA are associated with its progression rate, we hypothesized that a non circular configuration has a higher growth rate. Index of non circularity was developed on color photographs and was a strong predictor …
Ronald P. Danis, Amitha Domalpally, Larry D. Hubbard, Ashwini Narkar, James White, Emily Chew, Traci Clemons Abstract Purpose: We evaluated a parameter based upon an indirect measure of the extent to which the shape of an area of GA in an eye departs from that of a circle as a risk factor for rate of …
Amitha Domalpally, Ronald P Danis, Ashwini Narkar, Barbara A. Blodi, Emily Chew, Traci Clemons Abstract Purpose: To evaluate the features associated with progression of Geographic Atrophy (GA) from Autofluorescence (AF) images. Methods: AF images (from scanning laser ophthalmoscopy) images are captured at annual visits in the Age Related Eye Disease Study 2 (AREDS2) ancillary study. …
Jane R. Armstrong, James White, Amitha Domalpally, Ronald P. Danis, Barbara Blodi, Qian Peng, Michael L. Klein, AREDS2 Research Group. Abstract Purpose: To assess retinal precursors of Geographic atrophy (GA) in digital images from the AREDS2 data set. Methods: The Age Related Eye Disease Study 2 (AREDS2) is a multi-center randomized trial of 4,200 participants …