Ronald P Danis, Amitha Domalpally, Ralph Trane, Jeong W Pak Abstract Purpose: To quantitatively evaluate the relationship between drusen area from photographs and drusen [a1.1]volume from SDOCT volume scans with respect to baseline association, AREDS Severity Scale, and change in these measurements over time. Methods: In a set of 88 eyes with non-advanced AMD (median …
Eric Weinlander, Amitha Domalpally, Ellie Corkery, Barbara Blodi Abstract Purpose: Spectral domain optical coherence tomography (SD-OCT) has not routinely been used to measure features of polypoidal choroidal vasculopathy (PCV) due to its anatomic complexity. We hypothesize that a novel algorithm-based semi-automated approach to grading SD-OCT will overcome this difficulty to yield reliable and accurate measurements …
Amitha Domalpally, Yijun Huang, Dawn Myers, Taylor Starnes, Zhe Liu, Ronald P. Danis, Barbara A. Blodi Abstract Purpose: To compare retinal pigment epithelium (RPE) and retinal thickness assessments made with SDOCTin eyes with dry AMD and normal eyes. Methods: Eyes with intermediate AMD or worse in participants between 50 – 85 years of age were …
Amitha Domalpally, Ronald Danis, Emily Chew, Srinivas Sadda, Traci Clemons, Thomas R Friberg, and the AREDS2 Research Group Abstract Purpose: To characterize abnormalities in the peripheral retina using ultrawidefield (UWF) autofluorescence (AF) images in eyes with age related macular degeneration (AMD) Methods: UWF images (200 degrees) centered on the posterior pole as well as steered …
Erika Treichel, Amitha Domalpally, Ronald Danis, Susan Reed, Ashwini Narkar, Traci Clemons, Emily Chew, and the AREDS2 Research Group Abstracts Purpose: To describe the methodology for evaluation of cortical and posterior subcapsular cataracts using digital fundus reflex photographs and the baseline lens data in AREDS2. The goal of AREDS2 is to study the effects of …
Yijun Huang, Ronald P Danis, Jeong W. Pak, Shiyu Luo, James White, Xian Zhang, Ashwini Narkar, Amitha Domalpally Abstract Purpose: To develop a computer-aided manual segmentation method (EdgeSelect) for SD-OCT images, and compare its segmented results with those using a traditional manual segmentation (Manual) method. Methods: 3D Spectralis SD-OCT images (Heidelberg Inc., Germany) covering the …
Ronald P. Danis, Amitha Domalpally, Ellie Corkery, Ruth Shaw, Ashwini Narkar, Jim White Abstract Purpose: Given that baseline area and configuration of GA are associated with its progression rate, we hypothesized that a non circular configuration has a higher growth rate. Index of non circularity was developed on color photographs and was a strong predictor …
Jeong W. Pak, Amitha Domalpally, Dawn Myers, Xiufen Yang, Ashwini Narkar, Yijun Huang, and Ronald P. Danis Abstract Purpose: To characterize drusen morphology and retinal layer abnormalities by simple, ordinal description and to associate these features with drusen progression over one year on SD-OCT scans. Methods: Twenty two pairs of SD-OCT macular volume scans at …
Ronald P. Danis, Amitha Domalpally, Larry D. Hubbard, Ashwini Narkar, James White, Emily Chew, Traci Clemons Abstract Purpose: We evaluated a parameter based upon an indirect measure of the extent to which the shape of an area of GA in an eye departs from that of a circle as a risk factor for rate of …
Amitha Domalpally, Ronald P Danis, Ashwini Narkar, Barbara A. Blodi, Emily Chew, Traci Clemons Abstract Purpose: To evaluate the features associated with progression of Geographic Atrophy (GA) from Autofluorescence (AF) images. Methods: AF images (from scanning laser ophthalmoscopy) images are captured at annual visits in the Age Related Eye Disease Study 2 (AREDS2) ancillary study. …