Kristi Dohm, Mozhdeh Bahrainian, Nancy Barrett, Rick Voland, John Garrett, Jomol Mathew, Michael D. Abramoff, Barbara Blodi, Amitha Domalpally, Roomasa Channa Abstract Purpose: Validity of diabetic retinal disease (DRD) severity level as documented in electronic health record (EHR) data is crucial for research and patient care. Our goal was to assess the validity of DRD …
Mohammed Younis, Robert D. Slater, Caleb Pacheco, Sairi Zhang, Rick Voland, Rachel E. Linderman, Roomasa Channa, Amitha Domalpally Abstract Purpose: To develop and validate a transfer learning model for measuring geographic atrophy (GA) area using ultrawide field (UWF) fundus autofluorescence (FAF) imaging. The model was initially trained and validated on Heidelberg Spectralis images and subsequently …
Mary Wilda, Rachel Halweg, Cynthia Hurtenbach, Kristi Dohm, Justin Parks, Ruth Shaw, Sheila Watson, Kari Moseman, Rick Voland, Barbara A. Blodi Abstract Purpose: To investigate the reproducibility of nonperfusion area measurements from ultrawide field fluorescein angiograms (UWF-FA) within each zone of the NetwORC grid and the reproducibility of change over time within each zone assessed …
Robert D. Slater, Apoorva Safai, Madeline Pflasterer-Jennerjohn, Jennifer Heathcote, Rachel E. Linderman, Pallavi Tiwari, Emily Chew, Amitha Domalpally Abstract Purpose: Geographic atrophy (GA) is the end stage of non-exudative AMD. Prevention strategies are essential to delay or prevent GA development. Identifying precursors of GA can help target individuals at risk and develop effective interventions. The …
Justin Bitner, Jeong W. Pak, Jessica Berg, Rick Voland, Ronald Danis, David Bingaman, Yijun Huang, Amitha Domalpally Abstract Purpose: To quantify geographic atrophy (GA) lesion area using the en face image of outer retina-choroid (ORC) derived from spectral domain-optical coherence tomography (SD-OCT) volume scans and to compare GA measurements among ORC, OCT, and fundus autofluorescence …
Britney A. Naolhu, Sairi Zhang, Jeong W. Pak, Rick Voland, Amitha Domalpally, Collin Rich, Mihai Mititelu Abstract Purpose: Mitochondrial dysfunction from oxidative stress disrupts retinal metabolic function, leading to diseases such as age-related macular degeneration (AMD). This study evaluates flavoprotein fluorescence (FPF), a novel biomarker of retinal distress, as a functional assessment tool for macular …